Tubulin Polymerization-IN-1 prodrug, CAS [[3033099-32-7]] Preis auf Anfrage

Product Overview

• Article Name: Tubulin Polymerization-IN-1 prodrug, CAS [[3033099-32-7]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-159921
• Supplier Catalog Number: HY-159921
• Alternative Catalog Number: MCE-HY-159921-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Tubulin Polymerization-IN-1 prodrug (Compound 2b) is a palladium (Pd)-mediated tubulin polymerization inhibitor prodrug. Developed based on colchicine binding site inhibitors (CBSIs), it reduces toxicity and enhances targeted release properties. Compared to the parent compound, Tubulin Polymerization-IN-1 prodrug exhibited 68.3-fold lower cytotoxicity, which can be restored in situ in the presence of Pd resin. Mechanistic studies showed that its anticancer activity is consistent with CBSIs. In vivo, Tubulin Polymerization-IN-1 prodrug significantly inhibited tumor growth (63.2%) when activated by Pd resin. It holds promise for research in the field of anticancer therapy[1].

Product Properties

• Molecular Weight: 398.43
• CAS Number: [3033099-32-7]
• Formula: C22H23FN2O4
• Target: Microtubule/Tubulin

Application Notes

• Application Notes: MCE Product type: Reference compound