HA-9104 is a potent and selective cullin-5 neddylation inhibitor with an IC50 of 33.29 µM. HA-9104 induces apoptosis by reducing the polyubiquitination modification of NOXA, prolonging the half-life of NOXA and causing its accumulation. HA-9104 forms DNA adducts, induces DNA damage, triggers replication stress and ROS production, and leads to G2/M cell cycle arrest. HA-9104 exhibits radiosensitizing effects. HA-9104 can be used in research related to lung cancer and pancreatic cancer[1][2].
Molecular Weight:
465.55
Purity:
98.54
CAS Number:
[2412367-83-8]
Formula:
C28H27N5O2
Target:
Apoptosis,DNA/RNA Synthesis,E1/E2/E3 Enzyme,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
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