DNA relaxation-IN-1 (Compound 27) is a DNA ligase 1 DNA Lig1) inhibitor. DNA relaxation-IN-1 inhibits DNA ligation and disrupts the DNA relaxing activity of DNA Lig1. DNA relaxation-IN-1 induces Apoptosis. DNA relaxation-IN-1, in combination with Topotecan (HY-13768), exhibits synergistic antiproliferative effects against colorectal cancer[1].
Molecular Weight:
493.62
Purity:
99.37
CAS Number:
[2190506-29-5]
Formula:
C30H27N3O2S
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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