CBI1 is a covalent BAX inhibitor. CBI1 selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 blocks t-2-hex lipidation and oligomerization of BAX. CBI1 inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex[1].
Molecular Weight:
415.37
Formula:
C15H19BrN4OS2
Target:
Bcl-2 Family
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
