Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (alphanybeta3), 8.4 nM (alphanybeta5) and 14.9 nM (alpha5beta1), respectively. Cilengitide inhibits the binding of alphanybeta3 and alphanybeta5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-beta/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers[1][2][3].
Molecular Weight:
588.66
Purity:
99.80
CAS Number:
[188968-51-6]
Formula:
C27H40N8O7
Target:
Apoptosis,Autophagy,Integrin,PD-1/PD-L1,STAT
Application Notes:
Reference compound
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