PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. PROTAC EGFR degrader 9 exhibits a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTAC EGFR degrader 9 exhibits potent degradation activity against various EGFR mutants, while sparing the EGFRWT. (Blue: CRBN ligand (HY-A0003), Black: linker (HY-161613), Pink: EGFR inhibitor (HY-161537))[1].
Molecular Weight:
899.98
Purity:
98.35
CAS Number:
[2992670-33-2]
Formula:
C45H48F3N9O6S
Target:
Apoptosis,EGFR,PROTACs
Application Notes:
MCE Product type: Reference compound1
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