HVH-2930 is an inhibitor for heat shock protein 90 (HSP90). HVH-2930 inhibits cell viability of BT474 (Trastuzumab (HY-P9907) sensitive) and JIMT-1 (Trastuzumab (HY-P9907) resistant), with IC50 of 6.86 µM and 4.42 µM, through downregulation of HSP90 clients HER2, p-HER2, AKT, p-AKT, cyclin D1 and survivin. HVH-2930 exhibits antitumor efficacy in mouse models. HVH-2930 exhibits good pharmacokinetic characteristics in mice[1].
Molecular Weight:
488.62
Purity:
96.54
CAS Number:
[3034605-72-3]
Formula:
C29H36N4O3
Target:
Akt,EGFR,HSP,Survivin
Application Notes:
MCE Product type: Reference compound
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