MS8847 is a highly potent EZH2 PROTAC degrader that recruits the E3 ligase von Hippel-Lindau (VHL). MS8847 potently degrades EZH2 in a ubiquitin-proteasome system-dependent manner. MS8847 effectively inhibits the growth of acute myeloid leukemia (AML) and triple-negative breast cancer (TNBC) cells[1].
Molecular Weight:
1239.65
Purity:
99.78
CAS Number:
[3050872-59-5]
Formula:
C70H98N10O8S
Target:
Histone Methyltransferase,PROTACs
Application Notes:
MCE Product type: Reference compound
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