MS8847 is a PROTAC degrader and antiproliferative agent targeting EZH2 (DC50=34.4 nM in EOL-1 MLL-rAML cells). MS8847 recruits the E3 ligase von Hippel-Lindau (VHL) to mediate the degradation of EZH2 via the ubiquitin-proteasome system. MS8847 induces antiproliferative effects in MLL-rearranged acute myeloid leukemia cells and inhibits the growth of triple-negative breast cancer cell lines or 3D triple-negative breast cancer models. MS8847 is applicable to research related to MLL-rearranged acute myeloid leukemia and triple-negative breast cancer[1].
Molecular Weight:
1239.65
Purity:
99.78
CAS Number:
[3050872-59-5]
Formula:
C70H98N10O8S
Target:
Histone Methyltransferase,PROTACs
Application Notes:
MCE Product type: Reference compound
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