AZ9567 is an orally active MAT2a inhibitor with a pIC50 of 9.1. AZ9567 binds to MAT2a allosterically, reduces the synthesis of SAM, decreases SDMA levels, and exerts antiproliferative effects on MTAP-knockout cells. AZ9567 depletes SAM, causes methionine accumulation in plasma and tissues, triggers adaptive disorders in one-carbon metabolism, transsulfuration metabolism and lipid metabolism, and induces oxidative stress, hepatic steatosis and lipid homeostasis imbalance. AZ9567 can be used in studies related to MTAP-deficient/deleted cancers[1][2][3].
Molecular Weight:
447.44
Purity:
99.21
CAS Number:
[3056570-19-2]
Formula:
C24H19F2N5O2
Target:
Methionine Adenosyltransferase (MAT)
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
