AP-4-139B is a blood-brain barrier-permeable HSP70 inhibitor with a IC50 of 180 nM against hHSP70. AP-4-139B binds directly to HSP70 and inhibits its ATPase activity. AP-4-139B promotes Autophagy by increasing the phosphorylation of Beclin-1. AP-4-139B exerts antitumor effects in preclinical models of colorectal cancer and pancreatic ductal adenocarcinoma[1][2].
Molecular Weight:
626.59
Purity:
98.87
CAS Number:
[2716909-84-9]
Formula:
C34H33BrN3PS
Target:
Autophagy,Beclin1,HSP
Application Notes:
MCE Product type: Reference compound
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