Lw13 is a Hsp90-targeting PROTAC and achieves maximum degradation at a concentration of 0.05 µM in Siha cells. Lw13 induces cell apoptosis and exhibits potent anti-tumor activity both in vitro and in vivo(Sturcture Note:(Blue: Cereblon ligand (HY-A0003), Black: linker,Pink: Hsp90 inhibitor SNX-5422 (HY-10213))[1].
Molecular Weight:
904.97
Formula:
C46H55F3N8O8
Target:
Apoptosis,HSP,PROTACs
Application Notes:
MCE Product type: Reference compound
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