AZ'3137 is an orally active PROTAC-type androgen receptor (AR) degrader with a DC50 value of 22 nM. AZ'3137 can degrade L702H mutant AR (DC50 of 92 nM). AZ3137 can inhibit cell proliferation of LNCaP, with a GI50 value of 74 nM. AZ3137 can inhibit AR signaling and tumor growth in prostate cancer mice (Pink: AR Ligand (HY-172954), Blue: CRBN ligand (HY-172955), Black: linker (HY-W262798), E3 Ligand+Linker: HY-172956)[1].
Molecular Weight:
801.87
Purity:
99.90
CAS Number:
[2960179-55-7]
Formula:
C43H47F4N7O4
Target:
Androgen Receptor,PROTACs
Application Notes:
MCE Product type: Reference compound
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