BSJ-5-63 is a potent CDK12, CDK7, CDK9 PROTAC degrader. BSJ-5-63 BSJ-5-63 decreases the protein expression of CDK12, CDK7, CDK9, RNAPII, Cyclin K. BSJ-5-63 decreases the mRNA expression of BRCA1, BRCA2. BSJ-5-63 shows anticancer activity and has the potential for the research of prostate cancer (Pink: ligand for target protein (HY-150948), black: linker (HY-W140827), Blue: E3 ligase ligand (HY-112078))[1].
Molecular Weight:
1020.78
Purity:
99.97
CAS Number:
[2519823-37-9]
Formula:
C52H74ClN9O6S2
Target:
CDK,PROTACs
Application Notes:
MCE Product type: Reference compound
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