hAChE-IN-8 (Compound S-12) is a orally effective and selective inhibitor of hAChE (IC50=0.486 µM). hAChE-IN-8 also inhibits BACE-1 (IC50=0.542 µM), and does not inhibit Dyrk1A (IC50>10 µM). hAChE-IN-8 can reduce Abeta aggregation, has good blood-brain barrier penetration. hAChE-IN-8 is mainly used in Alzheimers disease research[1].
Molecular Weight:
442.47
Formula:
C25H22N4O4
Target:
Cholinesterase (ChE),DYRK
Application Notes:
MCE Product type: Reference compound1
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