PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 µM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 (HY-163787), Black: linker (HY-163788), Blue: ligand for E3 ligase (HY-10984))[1]
Molecular Weight:
789.88
Purity:
98.88
CAS Number:
[3025082-14-5]
Formula:
C41H47N11O6
Target:
Apoptosis,CDK,PROTACs
Application Notes:
MCE Product type: Reference compound
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