GTCpFE inhibits IKKalpha/beta in the NF-kappaB pathway with anti-inflammatory activities and blocks p65 nuclear entry, which consists of Dimethyl fumarate (DMF) (HY-17363) linked to Aspirin (ASA) (HY-14654). GTCpFE exhibits selective anti-cancer stem-like cell (CSC) activity by reducing mammosphere growth and the CD44+ CD24- immunophenotype. GTCpFE inhibits breast cancer stem cells, an important NFkappaB- and PGE2-dependent phenotype in aggressive cancers[1][2].
Molecular Weight:
412.39
CAS Number:
[1588866-45-8]
Formula:
C22H20O8
Target:
IKK,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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