DMTr-2-O-C22-rG (ibu)-3-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2-O-C22-rG (ibu)-3-CE-Phosphoramidite enables site-specific introduction of 2-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2-O-C22-rG (ibu)-3-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2-O-C22-rG (ibu)-3-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules[1].
Molecular Weight:
1164.50
Purity:
98
CAS Number:
[2923115-75-5]
Formula:
C66H98N7O9P
Target:
DNA/RNA Synthesis,Phosphoramidites
Application Notes:
MCE Product type: Oligonucleotides
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