Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity. Pexidartinib has limited permeability to the blood-brain barrier, primarily through ABCB1[1][2][3][4][5][6][7].
Molecular Weight:
417.81
Purity:
99.64
CAS Number:
[1029044-16-3]
Formula:
C20H15ClF3N5
Target:
Apoptosis,c-Fms,c-Kit
Application Notes:
MCE Product type: Reference compound
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