PROTAC KSP degrader 1, CAS [[3099825-86-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-168725
Supplier Catalog Number:
HY-168725
Alternative Catalog Number:
MCE-HY-168725-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PROTAC KSP degrader 1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC50 of 114.8 nM. PROTAC KSP degrader 1 inhibits the proliferation of HCT-116 with IC50 of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP degrader 1 exhibits antitumor efficacy in mouse model[1]. (Blue: Ligand for E3 Ligase Cereblon (HY-103596), Blank: Linker (HY-168726), Pink: Target Protein Ligand (HY-168727))
Molecular Weight:
858.01
CAS Number:
[3099825-86-9]
Formula:
C48H51N5O8S
Target:
Apoptosis,Kinesin,PROTACs
Application Notes:
MCE Product type: Reference compound1
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