XJTU-L453 is a PI3Kalpha inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 µM and 0.5 µM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice[1].
Molecular Weight:
390.44
CAS Number:
[3008290-92-1]
Formula:
C22H22N4O3
Target:
Apoptosis,PI3K
Application Notes:
MCE Product type: Reference compound
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