JNK-1-IN-4, CAS [[3047795-60-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-169177
Supplier Catalog Number:
HY-169177
Alternative Catalog Number:
MCE-HY-169177-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
JNK-1-IN-4 (Compound E1) is an inhibitor for JNK, that inhibits JNK-1, JNK-2 and JNK-3 with IC50s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun, and reduces the expression of TGF-beta1-induced EMT marker proteins, such as fibronectin and alpha-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin (HY-17565)-induced mice idiopathic pulmonary fibrosis models[1].
Molecular Weight:
501.38
CAS Number:
[3047795-60-5]
Formula:
C22H25BrN6O3
Target:
JNK
Application Notes:
MCE Product type: Reference compound
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