(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity[1][2][3][4].
Molecular Weight:
387.51
Purity:
99.62
CAS Number:
[68392-35-8]
Formula:
C26H29NO2
Target:
Adhesion G Protein-coupled Receptors (AGPCRs),Drug Metabolite,Estrogen Receptor/ERR
Application Notes:
MCE Product type: Reference compound
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