cGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC50 of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC50 of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149)-induced acute liver injury in mouse models[1]. orally active, THP-1, C57Bl/6 mouse, orally active
Molecular Weight:
421.28
Purity:
99.42
CAS Number:
[2987886-49-5]
Formula:
C19H18Cl2N4O3
Target:
Cyclic GMP-AMP Synthase
Application Notes:
MCE Product type: Reference compound
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