YB-3-17 is a bifunctional molecule, that inhibits mTOR (IC50=0.22 nM) or degrades G1 to S phase transition 1 gene (GSPT1, DC50=5 nM) in a PROTAC mechanism. YB-3-17 exhibits antiproliferative activity in multi glioblastoma cell lines with IC50 of nanomolare levels. YB-3-17 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-170407), Black: linker (HY-A0102), Blue: ligand for E3 ligase Cereblon (HY-14658))
Molecular Weight:
745.79
CAS Number:
[2940242-88-4]
Formula:
C38H39N11O6
Target:
mTOR,PROTACs
Application Notes:
MCE Product type: Reference compound
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