Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 µM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-kappaB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI)[1].
Molecular Weight:
351.83
Purity:
98.47
CAS Number:
[2450279-41-9]
Formula:
C19H18ClN5
Target:
Cathepsin,Interleukin Related,JAK,p38 MAPK,STAT
Application Notes:
MCE Product type: Reference compound
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