P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-beta/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis[1].
Molecular Weight:
362.36
CAS Number:
[1358201-44-1]
Formula:
C20H15FN4O2
Target:
CDK,TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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