TFGF-18 is a GSK-3beta inhibitor (IC50: 0.59 µM). TFGF-18 inhibits LPS-induced microglia activation and proinflammatory mediators release via inhibiting GSK-3beta and downstream p65/NF-kappaB signaling. TFGF-18 inhibits neuronal apoptosis and oxidative stress, inhibits expressions of Bax, caspase3 and cleaved-caspase3 and increases the expression of Bcl-2. TFGF-18 has neuroprotection effect, inhibit neuroinflammation and attenuates cognitive impairment[1][2].
Molecular Weight:
613.53
CAS Number:
[2222662-20-4]
Formula:
C28H30F3NO11
Target:
Apoptosis,Bcl-2 Family,Caspase,GSK-3,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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