Amyloid-beta-IN-3 (EX.113) is a selective gamma-secretase inhibitor. Amyloid-beta-IN-3 inhibits Abeta42 secretion in H4 cells with an EC50 value of 148 nM. Amyloid-beta-IN-3 regulates the gamma-secretase catalytic activity to decrease Abeta42 production, thereby alleviating neurotoxicity caused by Abeta deposition. Amyloid-beta-IN-3 is promising for research of Alzheimers disease (AD)[1].
Molecular Weight:
397.42
Purity:
99.50
CAS Number:
[1603833-56-2]
Formula:
C22H21F2N3O2
Target:
Amyloid-beta,gamma-secretase
Application Notes:
MCE Product type: Reference compound
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