SK2188 is a highly efficient and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM). SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252), Blue: Thalidomide (HY-14658), Black: Linker: Amino-PEG4-alcohol (HY-W008005))[1].
Molecular Weight:
893.38
Purity:
99.87
CAS Number:
[3038446-94-2]
Formula:
C43H46ClFN6O10S
Target:
Apoptosis,Aurora Kinase,Caspase,PROTACs
Application Notes:
MCE Product type: Reference compound
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