FC-14369 is a PROTAC degrader targeting HIV-1 Nef protein with a DC50 value of 160 nM. FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase via its bifunctional structure, inducing Nef ubiquitination and proteasomal degradation to restore cell-surface CD4 and MHC-I expression and inhibit HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS[1]. (Pink: Nef ligand-2 (HY-171862), Black: Ethylenediamine (HY-Y0275), Blue: Thalidomide (HY-14658))
Molecular Weight:
855.22
Purity:
97.85
CAS Number:
[3066894-28-5]
Formula:
C42H34ClF3N8O7
Target:
HIV,PROTACs
Application Notes:
MCE Product type: Reference compound
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