BI-4659 (Compound 47i) is a TGF-beta type I receptor (TGF-betaRI) (Alk5) inhibitor with an IC50 of 19 nM. BI-4659 also inhibits (IC50: 99 nM) and significantly blocks TGFbetaRI-mediated phosphorylation of Smad2/3 with low cross-reactivities within the human kinome. BI-4659 can be used for fibrotic diseases like idiopathic pulmonary fibrosis (IPF) and cancers research[1].
Molecular Weight:
440.54
CAS Number:
[894784-05-5]
Formula:
C27H28N4O2
Target:
PDGFR,TGF-beta/Smad,TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
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