BI-4659 is a TGFbetaRI and PDGFRalpha inhibitor with IC50 values of 19 nM and 99 nM, respectively. BI-4659 inhibits the kinase activities of TGFbetaRI and PDGFRalpha, blocks the downstream TGFbetaRI signaling pathway, and reduces the phosphorylation level of Smad2/3 without altering the expression of TGF-beta1. BI-4659 is applicable to research related to pulmonary fibrosis, cancer, and renal ischemia-reperfusion injury[1][2].
Molecular Weight:
440.54
Purity:
99.78
CAS Number:
[894784-05-5]
Formula:
C27H28N4O2
Target:
PDGFR,TGF-beta/Smad,TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
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