PROTAC cGAS degrader-1 is a potent and selective cGAS PROTAC degrader, with DC50 values of 0.9 µM and 4.6 µM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 induces proteasome-mediated degradation of cGAS, inhibits the cGAS signaling pathway, and attenuates double-stranded DNA-induced activation of cGAS in human and mouse cells. PROTAC cGAS degrader-1 is applicable to research related to ulcerative colitis[1].
Molecular Weight:
714.60
Purity:
99.07
CAS Number:
[3118499-89-8]
Formula:
C36H33Cl2N7O5
Target:
Cyclic GMP-AMP Synthase,PROTACs
Application Notes:
MCE Product type: Reference compound
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