PROTAC cGAS degrader-1 (Compound TH35) is an effective and selective cGAS PROTAC degrader, with DC50 values of 0.9 µM and 4.6 µM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 can inhibit the activation of cGAS signaling induced by dsDNA. PROTAC cGAS degrader-1 has anti-inflammatory activity and can be used in the research of cGAS-related inflammatory diseases. (Pink: cGAS inhibitor (HY-133916), Black: Linker (HY-W411604), Blue: E3 ligase ligand (HY-43722))[1]
Molecular Weight:
714.60
Purity:
99.07
Formula:
C36H33Cl2N7O5
Target:
Cyclic GMP-AMP Synthase,PROTACs
Application Notes:
MCE Product type: Reference compound
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