LZ-07 is a IRAK4 PROTAC degrader (DC50 = 1.14 nM). LZ-07 leads to marked suppression of cytokines including IL-6, IL-1beta, TNF-alpha, and IL-10 upon degradation of IRAK4. LZ-07 can be studied in research for autoimmune diseases (Pink: IRAK4 ligand (HY-172591), Blue: CRBN ligand (HY-34590), Black: linker (HY-B0149), CRBN ligand + linker: HY-172593)[1].
Molecular Weight:
812.92
Formula:
C42H48N14O4
Target:
Interleukin Related,IRAK,PROTACs,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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