PI3K-IN-58, CAS [[3067572-78-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-172886
Supplier Catalog Number:
HY-172886
Alternative Catalog Number:
MCE-HY-172886-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PI3K-IN-58 (Compound 17f) is a PI3Kalpha inhibitor (IC50: 0.039 µM). PI3K-IN-58 exhibits significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231 and MDA-MB-453 cell lines with IC50s of 3.48 µM, 1.06 µM, 2.21 µM and 0.93 µM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression levels of anti-apoptotic proteins Bcl-XL and Bcl-2 and upregulating the expression of anti-apoptosis protein BAX. PI3K-IN-58 can be used in PI3K-targeted cancer research[1].
Molecular Weight:
450.51
CAS Number:
[3067572-78-2]
Formula:
C22H22N6O3S
Target:
Apoptosis,Bcl-2 Family,PI3K
Application Notes:
MCE Product type: Reference compound
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