CLPP-2068 is the orally active activator for human caseinolytic protease P (HsClpP) with an EC50 of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC50 of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models[1].
Molecular Weight:
464.36
Purity:
97.41
CAS Number:
[3104462-62-3]
Formula:
C23H22BrN5O
Target:
Apoptosis,ClpP,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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