BRD6257 is a selective, orally active PPM1D inhibitor with an IC50 of 5 nM. BRD6257 increases the phosphorylation level of CHK2, activates the TP53 pathway by elevating p21 levels, and reduces the survival rate of wild-type TP53 cancer cells. BRD6257 can be used in leukemia research[1].
Molecular Weight:
550.53
Formula:
C24H22F4N6O3S
Target:
Checkpoint Kinase (Chk),MDM-2/p53,Phosphatase
Application Notes:
MCE Product type: Reference compound
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