(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9, VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-kappaB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S,R,S)-AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL)[1].
Molecular Weight:
560.71
Purity:
98.56
CAS Number:
[2086298-33-9]
Formula:
C28H40N4O6S
Target:
MALT1
Application Notes:
MCE Product type: Reference compound
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