15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARgamma. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1beta and TNF-alpha in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases[1].
Molecular Weight:
312.39
Formula:
C17H16N2O2S
Target:
COX,Interleukin Related,Lipoxygenase,PPAR
Application Notes:
MCE Product type: Reference compound
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