CB039 is a selective a molecular glue degrader that targets RBM39 (RNA-binding protein 39). CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer[1].
Molecular Weight:
481.52
CAS Number:
[3056259-55-0]
Formula:
C23H23N5O5S
Target:
Molecular Glues
Application Notes:
MCE Product type: Reference compound
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