SARM1-IN-4 is an orally active SARM1 inhibitor, with IC50 values of 0.31 µM, 0.318 µM, and 0.253 µM against human, mouse, and rat SARM1, respectively. SARM1-IN-4 reduces plasma neurofilament light chain levels and blocks warfarin-induced axonal degeneration. SARM1-IN-4 exhibits neuroprotective activity in mouse models, but paradoxical SARM1 activation occurs at low oral doses. SARM1-IN-4 can be used in studies of peripheral nerve injury[1].
Molecular Weight:
285.29
CAS Number:
[3069378-18-0]
Formula:
C13H17F2N3O2
Target:
Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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