Brefeldin A 4-O-nicotinate, CAS [[3035018-34-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-173280
Supplier Catalog Number:
HY-173280
Alternative Catalog Number:
MCE-HY-173280-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
CHNQD-01228
Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC50 value for the proliferation of T24 cells is 0.22 µM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer[1].
Molecular Weight:
385.45
CAS Number:
[3035018-34-6]
Formula:
C22H27NO5
Target:
Arf Family GTPase,BMX Kinase
Application Notes:
MCE Product type: Reference compound
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