EXO1-IN-1 is a human exonuclease 1 (EXO1) inhibitor (IC50 = 15.7 µM). EXO1-IN-1 inhibits DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase polyamylation. EXO1-IN-1 induces apoptosis (Apoptosis) in BRCA1-deficient breast cancer cells. EXO1-IN-1 suppresses the growth of BRCA1-deficient breast cancer xenografts. EXO1-IN-1 can be used in research related to BRCA1-deficient breast cancer[1].
Molecular Weight:
465.56
Purity:
99.00
CAS Number:
[1111188-09-0]
Formula:
C25H27N3O4S
Target:
Apoptosis
Application Notes:
MCE Product type: Reference compound
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