7,4-Dimethoxy-3-hydroxyflavone, CAS [[13198-99-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-174829
Supplier Catalog Number:
HY-174829
Alternative Catalog Number:
MCE-HY-174829-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
7,4-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 µM. 7,4-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-kappaB, Ca2+/protein kinase C, Akt, ERK and p38. 7,4-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) (HY-13753)-induced diabetic mice. 7,4-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time[1][2].
Molecular Weight:
298.29
CAS Number:
[13198-99-7]
Formula:
C17H14O5
Target:
Akt,Calcium Channel,ERK,NF-kappaB,p38 MAPK,PKC,Protease Activated Receptor (PAR),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
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