AF151 is a METTL3 PROTAC degrader with the DC50 of 0.43 µM in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading METTL3 protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia (AML). (Pink: METTL3 Ligand (HY-174874), Blue: VHL Ligand (HY-125845), Black: Linker, VHL Ligand+Linker (HY-174875))[1].
Molecular Weight:
1043.32
Purity:
98.87
Formula:
C61H70N8O6S
Target:
Apoptosis,Bcl-2 Family,METTL3,PROTACs
Application Notes:
MCE Product type: Reference compound1
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