VCP/p97 IN-3, CAS [[3098437-66-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-174984
Supplier Catalog Number:
HY-174984
Alternative Catalog Number:
MCE-HY-174984-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC50 of 9 nM and the mutant VCP proteins with IC50 of 12 nM (N660K) and 19 nM (V474A/D649A). VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma[1].
Molecular Weight:
606.69
CAS Number:
[3098437-66-9]
Formula:
C31H32F2N6O3S
Target:
Caspase,p62,p97
Application Notes:
MCE Product type: Reference compound
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