EGFR-IN-12 (Standard), CAS [[879127-07-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-17499R
Supplier Catalog Number:
HY-17499R
Alternative Catalog Number:
MCE-HY-17499R-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
EGFR-IN-12 (Standard) is the analytical standard of EGFR-IN-12. This product is intended for research and analytical applications. EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM. EGFR-IN-12 also inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity[1][2].
Molecular Weight:
413.40
CAS Number:
[879127-07-8]
Formula:
C21H18F3N5O
Target:
Apoptosis,EGFR,Reference Standards
Application Notes:
MCE Product type: Reference Standards
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