RIPK2-IN-8, CAS [[3036254-29-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-175026
Supplier Catalog Number:
HY-175026
Alternative Catalog Number:
MCE-HY-175026-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor (IC50 = 11 nM). RIPK2-IN-8 is highly selective for RIPK2 over RIPK1 (IC50 > 30,000 nM) and has a moderate inhibitory effect on RIPK3 (IC50 = 44.61 nM). RIPK2-IN-8 inhibits the NOD2-RIPK2 signaling pathway and the expression of the inflammatory cytokines IL-6 and TNFalpha, thereby exerting anti-inflammatory effects. RIPK2-IN-8 has demonstrated anti-inflammatory and hepatoprotective effects in an acute liver injury (ALI) model and can be used in ALI research[1].
Molecular Weight:
453.56
CAS Number:
[3036254-29-9]
Formula:
C22H20FN5OS2
Target:
Interleukin Related,NF-kappaB,p38 MAPK,RIP kinase
Application Notes:
MCE Product type: Reference compound
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