PROTAC c-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader with DC50s of 0.42 and 0.32 nM in EBC-1 and Hs746T cells, respectively. PROTAC c-Met degrader-5 significantly induces cell apoptosis, G1 cell cycle arrest, and inhibits cell migration and invasion. PROTAC c-Met degrader-5 has potent antiproliferative and degradation efficacy against c-Met-addicted cancer cells and Tepotinib (HY-14721)-resistant cancer cells[1]. Pink: c-Met ligand (HY-W425461), Blue: CRBN ligase ligand (HY-14658), Black: linker
Molecular Weight:
846.93
Formula:
C47H46N10O6
Target:
Apoptosis,c-Met/HGFR,PROTACs,STAT
Application Notes:
MCE Product type: Reference compound
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