RSL3-NH2 is a GPX4 inhibitor and ferroptosis (ferroptosis) inducer. RSL3-NH2 triggers the iron-dependent cell death pathway associated with lipid peroxidation by inhibiting GPX4 activity. RSL3-NH2 exhibits significant cytotoxicity against colorectal cancer cells and effectively induces their ferroptosis. RSL3-NH2 can serve as a ADC payload for synthesizing antibody-drug conjugates (ADC) and be used in colorectal cancer-related research[1].
Molecular Weight:
397.85
CAS Number:
[3051815-39-2]
Formula:
C21H20ClN3O3
Target:
ADC Payload,Ferroptosis,Glutathione Peroxidase
Application Notes:
MCE Product type: Reference compound1
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