AChE-IN-94 is an orally active and blood-brain barrier penetrable AChE inhibitor with an IC50 of 0.40 µM and Ki of 0.28 µM. AChE-IN-94 prevents self-induced and AChE-mediated Abeta1-42 aggregation. AChE-IN-94 alleviates cognitive/memory deficits in Scopolamine (HY-N0296)-induced amnesic model. AChE-IN-94 can be used for the study of Alzheimers disease (AD)[1].
Molecular Weight:
432.90
Formula:
C20H18ClFN4O2S
Target:
Amyloid-beta,Cholinesterase (ChE)
Application Notes:
MCE Product type: Reference compound
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